The United States and Iran are set to hold a fifth round of talks over the latter's nuclear program in Rome, and the stakes couldhardly be higher.

The main obstacle is Irans uranium enrichment capability -- something that the United States insists must be abandoned in any deal to ensure Iran will not weaponize its nuclear program.

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But retaining the ability to enrich uranium has become a matter of principle for Iran, with Foreign Minister Abbas Araqchi saying enrichment will continue with or without a deal.

Araqchi set the tone before departing Tehran for the Italian capital on May 23,writing on Xthat clinching a deal came down to whether the US would relax its position on enrichment.

Figuring out the path to a deal is not rocket science, Araqchi wrote, time to decide.

The Trump administration maintains that Iran must completely stop its enrichment activities -- a stance that US special envoy Steve Witkoff recently described as essential because enrichment enables weaponization.

Echoing this position, Secretary of State Marco Rubio told a Senate committee on May 21 that any level of domestic enrichment is unacceptable and poses a direct threat.

Witkoff, who has been representing the United States in the talks, has shifted his position since the Oman-mediated negotiations started in April. At one point, he suggested that Washington would agree to Iran enriching uranium to 3.67 percent purity -- as set under the 2015 nuclear accord that Trump abrogated in his first time in office.

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One idea put forward to salvage the talks and reach an agreement is the establishment of a regional nuclear consortium that would include Iran, Saudi Arabia, and the United Arab Emirates, with the potential for American involvement.

Araqchi this week said Iran was not opposed to the idea but insisted no initiative would result in Iran giving up the ability to enrich uranium on its soil.

A new report this week by the US Defense Intelligence Agency said Iran almost certainly is not producing nuclear weapons but has undertaken activities in recent years that better position it to produce them, if it chooses to do so.

Iran is currently enriching uranium to 60 percent purity, which is close to weapons-grade levels, and has said that while it is willing to scale it back, it needs uranium enriched at 20 percent for its Tehran reactor.

Meanwhile, European powers have threatened to trigger the 2015 deals snapback of UN sanctions against Iran if it fails to reach a deal with the United States by the end of June. The power to use the mechanism expires in October, so Iran, which has warned of consequences if the sanctions return, is in a race against time.

Separately, Israel is reportedly preparing to strike Iranian nuclear sites in the absence of a deal, prompting Araqchi to warn of special measures Iran would take if attacked.